Thanks to scientific progress and technological advancement, peptides have been developed with a focus on regulating sleep cycles, studied within the context of insomnia and other sleep disorders.
DSIP, or Delta Sleep Inducing Peptide, is a peptide that occurs naturally in the hypothalamus and pituitary gland [ii], among other brain regions. It has been suggested via research study findings that DSIP may improve sleep regulation, decrease motor activity to boost deep sleep, increase ACTH and LH levels, and normalize blood pressure. Researchers are optimistic that narcolepsy, hypertension, and insomnia might be mitigated with the help of DSIP with further refinements [iii].
The first DSIP was isolated from the cerebral venous blood of a sleeping rabbit brain in the 1970s; it is a naturally occurring neuropeptide. Synthesis of DSIP in rabbits occurs in the hypothalamus, and the peptide subsequently moves to its many CNS destinations.
After further research, scientists identified the brain regions where DSIP is most concentrated, including the thalamus, cerebral cortex, and cerebellum. Studies suggest serum levels of hormones, including corticotropin, somatostatin, serotonin, etc., might be affected by DSIP.
Epitalon is a manufactured analog of the naturally occurring neurotransmitter Epithalamin. Findings imply that the peptide may improve the neuroendocrine system and help regulate T-cells.
However, it has also been found by researchers to hold some potential in regulating sleep patterns, and its implied action in deep sleep makes it an intriguing compound for study [iv]. Its mode of action requires more investigation. The sleep-wake cycle-regulating pineal gland appears to be disrupted.
The Russian chemist Vladimir Khavinson first identified this synthetic peptide. Since then, the St. Petersburg Institute of Bioregulation and Gerontology has been at the front of research on Epitalon.
Investigations purport that Epitalon is an artificial telomerase activator enzyme that may possibly stimulate the pineal gland to produce telomerase enzymes. Thus, even after many cell divisions, telomeres may potentially be maintained, and more may be accessible at the ends of DNA strands.
Researchers also speculate that Epitalon may increase melatonin synthesis and control its release. Since melatonin production is essential in maintaining a healthy sleep-wake cycle, this may help reestablish a natural circadian rhythm. Epitalon is a synthetic pineal peptide suggested in research studies to affect gonadotropin levels.
Scientists hypothesize Sermorelin is a peptide that may stimulate growth hormone (hGH) [v]. Studies suggest the peptide may support sleep cycle development and REM sleep. Research suggests Sermorelin’s other properties might encompass muscle growth, increased reproductive activity, and rapid tissue repair.
The acetate salt of the synthetic peptide Sermorelin consists of 29 amino acids. The 44 amino acid residues in natural growth hormone-releasing hormone (GHRH) appear mimicked by this synthetic peptide (GRF 1-29 NH2).
The anterior pituitary gland is home to the growth hormone-releasing hormone receptors (GHRHr). By binding to these receptors, studies suggest Sermorelin may stimulate somatotroph cells to produce and secrete more growth hormone (GH).
When the blood concentration of growth hormone (GH) rises, another endogenous hormone termed somatostatin, also known as growth hormone inhibiting hormone (GHIH), is stimulated to maintain the appropriate hormonal balance.
To prevent an imbalance, the somatotroph cells use a negative feedback system activated by growth hormone inhibiting hormone (GHIH) to cease secreting growth hormone (GH).
AOD 9604 Peptide
Growth hormone (hGH) is the primary synthetic component of AOD 9604. Research suggests that it may host potential to induce lipolysis and lipogenesis, therefore the AOD 9604 peptide has gained some scientific awareness.
Research findings imply the compound may reduce mental and cognitive strains and improve sleep (6). While in sleep, investigations purport that AOD 9604 may stabilize metabolism and boost recovery. However, these ancillary potential actions are still under investigation.
The growth hormone (hGH) C-terminus fragment (AOD 9604) is a synthetic analog of this region (176-191). By increasing lipolysis and decreasing lipogenesis, this hexadecapeptide has been suggested to exert action in fat metabolism. Without affecting metabolism as a whole, research suggests AOD 9604 may increase fat breakdown in fat-rich locations.
Peptides and Sleep
Sleep peptides are those amino acid chains that have been suggested under research conditions to potentially institute some regulation and control over sleep cycles. Deep Sleep Inducing Peptide (DSIP) and other peptides for sale online are considered within the context of research in chronic pain mitigation as well as anxiety and withdrawal.
[i] Watson NF, Badr MS, Belenky G, Bliwise DL, Buxton OM, Buysse D, Dinges DF, Gangwisch J, Grandner MA, Kushida C, Malhotra RK, Martin JL, Patel SR, Quan SF, Tasali E. Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society. Sleep. 2015 Jun 1;38(6):843-4. doi: 10.5665/sleep.4716. PMID: 26039963; PMCID: PMC4434546.
[ii] Khvatova EM, Samartzev VN, Zagoskin PP, Prudchenko IA, Mikhaleva II. Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia. Peptides. 2003 Feb;24(2):307-11. doi: 10.1016/s0196-9781(03)00040-8. PMID: 12668217.
[iii] Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): an update. Peptides. 1986 Nov-Dec;7(6):1165-87. doi: 10.1016/0196-9781(86)90148-8. PMID: 3550726.
[iv] Khavinson V, Goncharova N, Lapin B. Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys. Neuro Endocrinol Lett. 2001 Aug;22(4):251-4. PMID: 11524632.
[v] Jessup SK, Malow BA, Symons KV, Barkan AL. Blockade of endogenous growth hormone-releasing hormone receptors dissociates nocturnal growth hormone secretion and slow-wave sleep. Eur J Endocrinol. 2004 Nov;151(5):561-6. doi: 10.1530/eje.0.1510561. PMID: 15538933.